An essential, practical manual for all those working in transfusion medicine
- Concise and user-friendly guide to transfusion medicine
- Focuses on clinical aspects but also covers background science and organizational issues
- Complications encountered in transfusion are addressed throughout
- Highlights controversial issues and provides advice for everyday clinical questions in transfusion medicine
This comprehensive guide to transfusion medicine takes a practical and didactic approach. The third edition of this text includes many new contributions and has expanded to seven sections. The first of these takes the reader systematically through the principles of transfusion medicine. The second deals with the complications which can arise in transfusion and is followed by a section on the practice of transfusion in blood centres and hospitals. The fourth section covers clinical transfusion practice and the fifth looks at alternatives to transfusion. Section six addresses cellular and tissue therapy and organ transplantation and the final section of the book examines the development of the evidence base for transfusion. As with previous editions; the final section includes a visionary chapter on future advances in the field.
This new edition of Practical Transfusion Medicine benefits from even more international authorship than the previous two editions and is an invaluable resource for trainee doctors, scientists, technicians and other staff in haematology and transfusion and as a reference book for clinical staff in haematology and other disciplines faced with specific problems.
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About the Author
Professor of Blood Transfusion Medicine, University of Oxford
Consultant Haematologist, NHS Blood&Transplant and Department of Haematology, The John Radcliffe Hospital, Oxford, UK
Derwood H. Pamphilon MD, MRCPCH, FRCP, FRCPath
Consultant Haematologist, NHS Blood&Transplant
Honorary Clinical Reader, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
Table of ContentsContributors.
Preface to the third edition.
Preface to the first edition.
1 Introduction: recent evolution of transfusion medicine (Ian M. Franklin).
Part 1 Basic principles of immunohaematology.
2 Essential immunology for transfusion medicine (Timothy Wallington).
3 Human blood group systems (Geoff Daniels).
4 Human leucocyte antigens (Cristina V. Navarrete).
5 Platelet and neutrophil antigens (David L. Allen, Geoffrey F. Lucas, Michael F. Murphy and Willem H. Ouwehand).
Part 2 Complications of transfusion.
6 Investigation of acute transfusion reactions (Nancy M. Heddle and Kathryn E. Webert).
7 Haemolytic transfusion reactions (Edwin Massey and Geoff Poole).
8 Febrile and allergic transfusion reactions (Cynthia Wu and Nancy M. Heddle).
9 Transfusion-related acute lung injury (Steven H. Kleinman and Ram Kakaiya).
10 Transfusion-related immunomodulation (Morris A. Blajchman and Eleftherios C. Vamvakas).
11 Transfusion-associated graft-versus-host disease and microchimerism (Beth H. Shaz and Christopher D. Hillyer).
12 Post-tranfusion purpura (Michael F. Murphy).
13 Tranfusion-transmitted infections (Alan D. Kitchen and John A.J. Barbara).
14 Bacterial contamination (Patricia E. Hewitt).
15 Variant Creutzfeldt–Jakob disease (Marc L. Turner).
16 Emerging infections and transfusion safety (Roger Y. Dodd).
Part 3 Practice in blood centres and hospitals.
17 Regulatory aspects of blood transfusion (Joan Jones and Adrian Copplestone).
18 The role of haemovigilance in transfusion safety (James P. AuBuchon).
19 Donors and blood collection (William Murphy and Ellen McSweeney).
20 Blood donation testing and the safety of the blood supply (David Wenham, Lisa Byrne and Simon J. Stanworth).
21 Production and storage of blood components (Rebecca Cardigan and Lorna M. Williamson).
22 Medicolegal aspects of transfusion practice (Patricia E. Hewitt).
23 Blood transfusion in hospitals (Sue Knowles and Geoff Poole).
24 Blood transfusion in a global context (David J. Roberts, Jean-Pierre Allain, Alan D. Kitchen, Stephen Field and Imelda Bates).
Part 4 Clinical transfusion practice.
25 Good blood management: the effective and safe use of blood components (Brian McClelland and Tim Walsh).
26 Prenatal and childhood transfusions (Irene Roberts).
27 Haematological disease (Michael F. Murphy and Simon J. Stanworth).
28 Blood transfusion in the management of patients with haemoglobinopathies (David Rees).
29 Massive blood loss (Beverley J. Hunt).
30 Inherited and acquired coagulation disorders (Vickie McDonald, J. Kim Ryland, Joanne E. Joseph and Samuel J. Machin).
31 Recombinant proteins in diagnosis and therapy (Marion Scott).
32 Immunodeficiency and immunoglobulin therapy (Siraj A. Misbah).
Part 5 Alternatives to transfusion.
33 The principles of bloodless medicine and surgery (Aryeh Shander and Lawrence Tim Goodnough).
34 Autologous transfusion (Dafydd Thomas and John Thompson).
35 Blood substitutes (Chris V. Prowse and David J. Roberts).
36 Pharmacological agents and recombinant factor VIIa (Beverley J. Hunt).
Part 6 Cellular and tissues therapy and organ transplantation.
37 Regulation and accreditation in cellular therapy (Derwood H. Pamphilon and Zbigniew M. Szczepiorkowski).
38 Stem cell collection and therapeutic apheresis (Khaled El-Ghariani).
39 Haemopoietic stem cell processing and storage (David H. McKenna Jr and Mary E. Clay).
40 Haemopoietic stem cell transplantation (I. Grant McQuaker and Ian M. Franklin).
41 Cord blood transplantation (Leandro de Padua Silva, Marcos de Lima, Elizabeth J. Shpall and Susan Armitage).
42 Recent advances in clinical cellular immunotherapy (Mark W. Lowdell and Emma Morris).
43 Cytokines in transfusion practice (Derwood H. Pamphilon and Michael F. Murphy).
44 Tissue banking (Ruth M. Warwick and Deirdre Fehily).
45 Transfusion strategies in organ transplant patients (Anneke Brand and Derwood H. Pamphilon).
Part 7 Development of the evidence base for transfusion.
46 The design of interventional trials in transfusion medicine (Paul C. H´ebert, Alan T. Tinmouth and Dean Fergusson).
47 Getting the most out of the evidence for transfusion medicine (Simon J. Stanworth, Susan J. Brunskill, Carolyn Doree and Chris J. Hyde).
48 How to influence clinicians’ use of blood – improving the transfusion practice in hospitals? (Simon J. Stanworth, J.J. Francis, M.P. Eccles, Chris J. Hyde, Michael F. Murphy and Alan T. Tinmouth).
49 Scanning the future of transfusion medicine (Walter H. Dzik).
Colour plates can be found facing page.
What People are Saying About This
"This book should be a standard reference volume in every blood bank and department of hematology in virtually every hospital. The editors should be commended for compiling such a readable text that is clear and easily understood which also contains consistent themes about transfusion practices and the dangers of allogenic blood." (SABM Newsletter, Summer 2010)