Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves.
Moreover, as part of the Academic Cell line of textbooks, this book contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles form the basis of case studies found in the associated online study guide that is designed to tie current topics to the scientific community.
- Contains new chapters on non-coding RNA, genome defense, epigenetics and epigenomics
- Features new and expanded coverage of RNAi, CRISPR, genome editing, giant viruses and proteomics
- Includes an Academic Cell Study Guide that ties all articles from the text with concurrent case studies
- Provides an updated, ancillary package with flashcards, online self-quizzing, references with links to outside content, and PowerPoint slides with images
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About the Author
David P. Clark did his graduate work on bacterial antibiotic resistance to earn his Ph.D. from Bristol University, in the West of England. During this time, he visited the British Government's biological warfare facility at Porton Down and was privileged to walk inside the (disused) Black Death fermenter. He later crossed the Atlantic to work as a postdoctoral researcher at Yale University and then the University of Illinois. David Clark recently retired from teaching Molecular Biology and Bacterial Physiology at Southern Illinois University which he joined in 1981. His research into the Regulation of Alcohol Fermentation in E. coli was funded by the U.S. Department of Energy, from 1982 till 2007. From 1984-1991 he was also involved in a project to use genetically altered bacteria to remove contaminating sulfur from coal, jointly funded by the US Department of Energy and the Illinois Coal Development Board. In 1991 he received a Royal Society Guest Research Fellowship to work at Sheffield University, England while on sabbatical leave. He has supervised 11 master’s and 7 PhD students and published approximately 70 articles in scientific journals. He has written or co-authored several textbooks, starting with Molecular Biology Made Simple and Fun (with Lonnie Russell; (Cache River Press, First edition, 1997) which is now in its fourth edition. Other books are Molecular Biology and Biotechnology (both published by Elsevier) He recently wrote a popular science book, Germs, Genes, & Civilization: How Epidemics Shaped Who We Are Today (2010, Financial Times Press/Pearson). David is unmarried, but his life is supervised by two cats, Little George and Mr Ralph.Nanette J. Pazdernik, Ph.D. is a co-author of Biotechnology, 2nd edition and Molecular Biology, 2nd edition, with Dr. David Clark. The second edition of Molecular Biology won a Texty award from the Textbook and Academic Authors Association in 2013. She has also authored an on-line study guide to accompany the update edition of Molecular Biology. She has taught courses in General Biology, Genetics, as well as Anatomy and Physiology at Southwestern Illinois College, McKendree University, and Harris-Stowe University. She received her BA in Biology from Lawrence University in Appleton, Wisconsin, in 1990 and her PhD in Molecular, Cellular, Developmental Biology and Genetics from the University of Minnesota in 1996. Her doctoral thesis studied how alterations in the structure of lactose permease affect its ability to transport sugar across the membrane of E. coli. Following her degrees, she investigated the IL-1 and TNF signal transduction pathways that control apoptosis and immunity at Indiana University School of Medicine. She has most recently studied the various molecules that maintain the stem cell fate in C. elegans at Washington University School of Medicine in St. Louis, MO. She is married and the mother of three children, ages 15, 12, and 8, which always make her realize the role biology plays in personality and development!Michelle R. McGehee earned a BA in Microbiology in 2000 and a PhD in Molecular Biology, Microbiology, and Biochemistry in 2005, both from Southern Illinois University in Carbondale, IL. Her graduate research focused on the genetic and biochemical regulation of lactate fermentation in Escherichia coli and was supervised by Dr. David P. Clark. After graduation, she accepted a postdoctoral research associate position at Texas A&M Health Science Center in College Station, TX, where she investigated the molecular pathogenesis of Borrelia burgdorferi. Prior to Molecular Biology, 3e, she contributed to the ancillary materials and online study guide for Molecular Biology’s first two editions, as well as to the ancillaries for the companion book Biotechnology, also published by Elsevier. She is currently a biology professor at a college in Texas, where she teaches courses in anatomy & physiology and both majors and non-majors microbiology. She also challenges high school students in science competitions as the state biology contest director for the University Interscholastic League through The University of Texas at Austin. In her spare time, she enjoys hiking and camping with her loyal partner, a border collie named Ria.
Table of Contents
Unit 1: Basic Chemical and Biological Principles 1. Cells and Organisms 2. Basic Genetics 3. DNA, RNA, and Protein 4. Genes, Genomes, and DNA 5. Manipulation of Nucleic Acids
Unit 2: The Genome 6. The Polymerase Chain Reaction 7. Cloning Genes for Analysis 8. DNA Sequencing 9. Genomicsand Systems Biology New Chapter to cover metagenomics, symbiosis, epigenomics etc
Unit 3: The Central Dogma of Molecular Biology 10. Cell Division and DNA Replication 11. Transcription of Genes 12. Processing of RNA (moved to Unit 4) 13. Protein Synthesis 14. Protein Structureand Function 15. Proteomics: Global Analysis of Proteins
Unit 4: Regulating Gene Expression 16. Regulation of Transcription in Prokaryotes 17. Regulation of Transcription in Eukaryotes 12. Processing of RNA (moved from Unit 3) 18. Regulation at the RNA Level New Chapter on Genome defense (RNAi and CRISPR). Would include their use in genetic analysis and genome editing 19. Analysis of Gene Expression (Transcriptome)
Unit 5: Subcellular Life Forms 20. Plasmids 21. Viruses 22. Mobile DNA
Unit 6: Changing the DNA Blueprint 23. Mutations and Repair 24. Recombination 25. Bacterial Genetics 26. Molecular Evolution