Sky Full of Moon gets under way when Vegas gambling-joint owner Al (Keenan Wynn) rescues rodeo rider Harley Williams (Carleton Carpenter) from drowning. Harley is then "adopted" as a good-luck charm by Al's change girl Dixie Delmar (Jan Sterling). When their lucky gambling streak comes to an end, so too does Harley and Dixie's romantic relationship. Though he practically has to have the moon fall on his head, Harley finally realizes that he's too naïve for life in the Fast Lane. The film's title derives from a line of dialogue delivered by Harley during his clumsy courtship of the hard-bitten Dixie.