Manhattan working girl Jean Arthur bids goodbye to her three erstwhile suitors (Grant Withers, Hans Conried and Grady Sutton) to take a bus tour of the west. En route, she meets handsome rodeo-star John Wayne, whose bucking bronco hurls him directly into her lap. Stranded in a tank town with Wayne and his sidekick Charles Winninger, Arthur is introduced to the sort of frontier activities not covered by the tour books: gambling, boozing and brawling. Not surprisingly, Arthur wants to hightail it back to the East, but by now Wayne has fallen in love with her. Lady Takes a Chance was produced for RKO by Jean Arthur's then-husband, Frank Ross.