Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.
Table of ContentsPreface.- Contents.- Note on Nomenclature.- Author Addresses.- Section 1Historical Introduction to Secreted Cell Stress Proteins as Signalling Proteins.- Chapter 1 Discovery of the Cellular Secretion of Cell Stress Proteins, Larry Hightower and Emily J. Noonan.- Chapter 2 Discovery of the Agonist Activities of Molecular Chaperones and Protein-Folding Catalysts, Brian Henderson.- Chapter 3 Identification of Cell Stress Proteins in Biological Fluids, A. Graham Pockley.- Section 2 Intracellular Trafficking of Molecular Chaperones and its Consequences.- Chapter 4 Hsp27 Phosphorylation Patterns and Cellular Consequences, Sergiy Kosteonko and Ugo Moens.- Chapter 5 Evidence on Cholesterol-Controlled Lipid Raft Interaction of the Small Heat Shock Protein HSPB11, Zsolt Török, Ana-Maria Pilbat, Imre Gombos, Enikő Hocsak, Balázs Sümegi, Ibolya Horváth and László Vígh.- Chapter 6Hsp70 Chaperone Systems in Vesicular Trafficking, David A. Parfitt, Daniel C. Campbell and J. Paul Chapple.- Chapter 7 Pathways of Hsp70 Release: Lessons from Cytokine Secretion, Ayesha Murshid and Stuart K Calderwood.- Chapter 8 Nucleolin: A Novel Intracellular Transporter of HSPA1A, Punit Kaur, Appukuttan R Pradeep and Alexzander Asea.- Chapter 9 The Hsp90-Based Protein Trafficking System and Linkage to Protein Quality Control, William B. Pratt, Yoshihiro Morishima, Andrew P. Lieberman, and Yoichi Osawa.- Section 3 Molecular Chaperones as Cell Surface Receptors and Receptor Ligands.- Chapter 10 Cell Surface Molecular Chaperones and the LPS receptor, Kathy Triantafilou.- Chapter 11 Hsp60: An Unexpected Cell Surface Receptor in Prokaryotes and Eukaryotes, Brian Henderson.- Chapter 12 Pathophysiological Barriers Impeding the Delivery of Heat Shock Protein (HSP)-based Macromolecules and Nanotherapeutics to Solid Tumors, Peter Vaupel and Gabriele Multhoff.- Chapter 13 The Chaperokine Activity of HSPA1A, Punit Kaur and Alexzander Asea.- Chapter 14 Molecular Chaperones and Scavenger Receptors: Binding and Trafficking of Molecular Chaperones by Class F and Class H Scavenger Receptors, Ayesha Murshid, Jianlin Gong and Stuart K Calderwood.- Chapter 15 Grp78 (BiP): A Multifunctional Cell Surface Receptor, Mario Gonzalez-Gronow, Salvatore V. Pizzo and Uma K. Misra.- Section 4 Extracellular Secretion of Molecular Chaperones in Prokaryotes and Eukaryotes.- Chapter 16 Mycobacterium tuberculosis Hsp60 as a Key Virulence Factor in Tuberculosis, Richard W. Stokes.- Chapter 17 Hsp90 vs Conventional Growth Factors in Acute and Diabetic Wound Healing, Wei Li, Kathryn O’Brien, David T. Woodley and Mei Chen.- Chapter 18 Circulating Molecular Chaperones in Health and Disease, Zoltán Prohászka.- Index